| Accepted Name |
| N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase. |
| Alternative Name(s) |
| Chondroitin glucuronyltransferase II. |
| Reaction catalysed |
- UDP-alpha-D-glucuronate + [protein]-3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine <=> UDP + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine
- UDP-alpha-D-glucuronate + [protein]-3-O-((beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3))(n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine <=> UDP + [protein]-3-O-(beta-D-GlcA-(1->3)-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3))(n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine
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| Comment(s) |
- Involved in the biosynthesis of chondroitin and dermatan sulfate.
- The human chondroitin synthetase is a bifunctional glycosyltransferase, which also has the EC 2.4.1.175 activity required for the synthesis of the chondroitin sulfate disaccharide repeats.
- Similar chondroitin synthase ‘copolymerases’ can be found in Pasteurella multocida and Escherichia coli.
- There is also another human protein with apparently only the 3-beta- glucuronosyltransferase activity.
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