| Accepted Name |
| 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase. |
| Alternative Name(s) |
| (Le(a))-dependent (alpha-3/4)-fucosyltransferase. |
| Alpha(1,3/1,4) fucosyltransferase III. |
| Alpha-(1->4)-L-fucosyltransferase. |
| Alpha-4-L-fucosyltransferase. |
| Beta-acetylglucosaminylsaccharide fucosyltransferase. |
| Blood group Lewis alpha-4-fucosyltransferase. |
| Blood-group substance Le(a)-dependent fucosyltransferase. |
| FucT-II. |
| Galactoside 3(4)-L-fucosyltransferase. |
| Guanosine diphosphofucose-beta-acetylglucosaminylsaccharide 4-alpha-L- fucosyltransferase. |
| Guanosine diphosphofucose-glycoprotein 4-alpha-fucosyltransferase. |
| Guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase. |
| Lewis alpha-(1->3/4)-fucosyltransferase. |
| Lewis blood group alpha-(1->3/4)-fucosyltransferase. |
| Lewis FT. |
| Lewis(Le) blood group gene-dependent alpha-(1->3/4)-L-fucosyltransferase. |
| Reaction catalysed |
| GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R <=> GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R |
| Comment(s) |
- Product of the Lewis blood group gene.
- Normally acts on a glycoconjugate where R (see CA line) is a glycoprotein or glycolipid.
- Although it is a 4-fucosyltransferase, it has a persistent 3-fucosyltransferase activity toward the glucose residue in free lactose.
- Fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3, unlike EC 2.4.1.152 which fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4.
- Enzymes catalyzing the 4-alpha-fucosylation of the GlcNAc in beta-D- Gal-(1->3)-beta-GlcNAc sequences (with some activity also as 3-alpha- fucosyltransferases) are present in plants, where the function in vivo is the modification of N-glycans.
- In addition, the fucTa gene of Helicobacter strain UA948 encodes a fucosyltransferase with both 3-alpha- and 4-alpha-fucosyltransferase activities.
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