EN01031 Pasteurella multocida Hyaluronan synthase (PmHAS)

Pasteurella multocida Hyaluronan synthase (PmHAS)

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Name Pasteurella multocida Hyaluronan synthase (PmHAS)
Catalog No. EN01031
E.C. 2.4.1.212
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SKU: EN01025 Categories: , , Tags: , , , ,

Description

Pasteurella multocida Hyaluronan synthase (PmHAS)

Accepted Name
Hyaluronan synthase.
Alternative Name(s)
HAS.
Reaction catalysed
  • UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) <=> UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan)
  • UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan) <=> UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan)
Cofactor(s)
Mg(2+).
Comment(s)
  • Adds GlcNAc to nascent hyaluronan when the non-reducing end is GlcA, but it adds GlcA when the non-reducing end is GlcNAc.
  • Highly specific for UDP-GlcNAc and UDP-GlcA; no copolymerization is observed if either is replaced by UDP-Glc, UDP-Gal, UDP-GalNAc or UDP-GalA.

Additional information

Pack

1 MG, 10 MG, 5 MG, Other

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