| Accepted Name |
| Globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase. |
| Alternative Name(s) |
| Beta-3GalNAc-T1. |
| Galactosylgalactosylglucosylceramide beta-D- acetylgalactosaminyltransferase. |
| Globoside synthase. |
| Globoside synthetase. |
| Uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide acetylgalactosaminyltransferase. |
| Reaction catalysed |
| UDP-N-acetyl-alpha-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide <=> UDP + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide |
| Cofactor(s) |
| Mn(2+). |
| Comment(s) |
- Globoside is a neutral glycosphingolipid in human erythrocytes and has blood-group-P-antigen activity.
- UDP-GalNAc is the only sugar donor that is used efficiently by the enzyme: UDP-Gal and UDP-GlcNAc result in very low enzyme activity.
- Lactosylceramide, globoside and gangliosides GM3 and GD3 are not substrates.
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